Cancer Malignancy Is Enhanced by Glyceraldehyde-Derived Advanced Glycation End-Products
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منابع مشابه
Cancer Malignancy Is Enhanced by Glyceraldehyde-Derived Advanced Glycation End-Products
The receptor for advanced glycation end-products (RAGEs) is associated with the malignancy of cancer. A recent study has suggested that glyceraldehyde-derived AGEs (Glycer-AGEs) enhanced the malignancy of melanoma cells, but glucose-derived AGEs did not. However, the effects of Glycer-AGEs on other cancer cells remain poorly understood, and the molecular mechanisms behind the above-mentioned ef...
متن کاملThe Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk.
BACKGROUND A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of com...
متن کاملGlyceraldehyde-Derived Advanced Glycation End Products Accumulate Faster Than Nε-(Carboxymethyl) Lysine
508 Ann Dermatol Received January 12, 2016, Revised July 8, 2016, Accepted for publication August 13, 2016 Corresponding author: Yoshihiro Tokudome, Laboratory of Dermatological Physiology, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. Tel: 81-49-271-8140, Fax: 81-49-271-8140, E-mail: tokudome@ josai.ac.jp This is an Open Access article di...
متن کاملAdvanced glycation end products, soluble receptor for advanced glycation end products, and risk of colorectal cancer.
BACKGROUND Advanced glycation end products (AGE) accumulate in human tissue proteins during aging, particularly under hyperglycemia conditions. AGEs induce oxidative stress and inflammation via the receptor for AGEs (RAGE) and soluble RAGE (sRAGE) can neutralize the effects mediated by RAGE-ligand engagement. METHODS We examined the association between N(ε)-(carboxymethyl)lysine (CML), a prom...
متن کاملAdvanced glycation end products
Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging have been proposed. In the last years advanced glycation end products (AGEs) have received particula...
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ژورنال
عنوان ژورنال: Journal of Oncology
سال: 2010
ISSN: 1687-8450,1687-8469
DOI: 10.1155/2010/739852